A one-week-old baby cries when he wakes up from sleep, which may be caused by physiological factors such as wet diapers and hunger, or other causes such as intussusception and vitamin D deficiency. 1. Physiological factors: one-week-old baby wet diapers are not replaced in time, the baby may feel uncomfortable, so that the performance of waking up crying. In addition, one-week-old babies feel hungry when they sleep, and will also appear to cry after waking up from sleep. 2. Intussusception: Intussusception may be caused by infection, abnormal intestinal development, and toddler polyps. Patients will have paroxysmal abdominal pain, blood in the stool, abdominal mass, abdominal distension and other manifestations. Therefore, one-week-old babies with intussusception may have the performance of waking up crying at bedtime due to abdominal pain. 3. Vitamin D deficiency: Vitamin D deficiency may be caused by insufficient sunshine and insufficient intake of vitamin D in food. The patient will present with excessive sweating, irritability, waking up at night, excessive sweating and other manifestations. If a one-week-old baby develops vitamin D deficiency, he or she may have the symptom of crying when waking up from sleep. One-week-old babies cry when they wake up from sleep, there may also be other reasons, it is recommended to go to the hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.