Nonoxynolone suppository is a kind of short-term contraceptive pill for women’s external use, after the use of the drug, women may occasionally have an allergic reaction, which may cause women’s vulva, vagina, and even men’s penis, the occurrence of more serious symptoms of irritation, such as localized itching, pain and so on. A few patients may have mild local irritation symptoms, such as increased vaginal discharge. Attention needs to be paid to observation when using the drug, and the drug should be terminated if there are severe irritation symptoms. In addition, the use of this drug should be prohibited for patients with suspected malignant tumors of the reproductive tract, as well as patients with irregular vaginal bleeding. The medicine must be placed deep into the vagina when it is administered, otherwise it may easily lead to contraceptive failure. When put into the medicine about five minutes before intercourse, if put into the 30 minutes without intercourse, in the intercourse must be put into the medicine again, repeat intercourse need to be put into the medicine again, six hours after intercourse before douching.