Symptoms of itchy skin in nephropathy may be caused by dry skin with varying degrees of skin flaking and follicular keratinization. It may also be toxin stimulation of peripheral sensory nerve endings itching. 1. Skin flaking: If the metabolites of patients with kidney disease are retained, resulting in skin irritation and atrophy of sebaceous glands and sweat glands, the skin may be dry and flaky to varying degrees and cause itching. 2. Follicular keratosis: follicular keratosis is mainly due to the loss-of-function mutation of calcium pump gene, which leads to changes in skin keratin-forming cells, thus causing hyperkeratosis of the skin. If elevated parathyroid hormone secretion causes hypercalcemia and calcium deposition in the skin, follicular keratosis may also occur to varying degrees. In addition, it may also be toxins stimulate the peripheral sensory nerve endings to appear itching. It is recommended that patients with kidney disease usually do not have too much psychological pressure, try not to eat greasy and stimulating food in the diet, avoid too much exertion, and pay more attention to rest. If the skin itching of kidney disease occurs, it is necessary to go to the hospital in a timely manner, to clarify the cause of the disease, and under the guidance of the doctor active treatment.