Melanin deposits at the corner of the lips can be removed by changing lifestyle habits, strengthening skin care, topical medications, laser treatment and other measures. 1. Change lifestyle habits: usually avoid using tissue paper and other products to wipe and stimulate the mouth repeatedly, at the same time eat more vitamin-rich fruits and vegetables, avoid staying up all night. 2. Enhance skin care: pay attention to sun protection, keep skin clean and hygienic, avoid the use of irritating cosmetics and skin care products and soap. 3. Topical medications: such as hydroquinone cream, vitamin E ointment, etc., have the effect of improving circulation, and have a certain auxiliary effect on the removal of melanin deposits on the corners of the lips. 4. Laser treatment: Fractional laser, picosecond and other measures can be taken to treat melanin deposits at the corner of the lips. Lip corner melanin precipitation has to improve the will to regular medical institutions, specialist physicians to choose the appropriate program after the interview for treatment, after the treatment need to pay attention to care.