Acne is usually referred to as acne, and the growth on both sides of the cheeks is usually related to exuberant sebaceous gland secretion, abnormal keratinization of the cells around the hair follicles, and Propionibacterium acnes infections, etc. If you are a female patient, you should also exclude polycystic ovary syndrome and other diseases. 1. Excessive sebum secretion: Due to physical development, androgen secretion is usually more vigorous in adolescent males and females, which causes sebaceous glands to produce more sebum, which will easily clog pores after mixing with exfoliated epidermal tissues, thus causing acne. 2. Abnormal keratinization of perifollicular cells: Abnormal keratinization of perifollicular cells will make the opening of the hair follicle smaller, narrower, and clogged, which prevents sebum from being discharged, thus easily causing acne. 3. Propionibacterium acnes infection: If the sebaceous glands of the hair follicles are locally infected by Propionibacterium acnes, it will easily cause inflammation of the sebaceous glands of the hair follicles and their surrounding tissues, resulting in the appearance of localized pimples, pustules, nodules and abscesses. At the same time, female acne also need to rule out polycystic ovary syndrome and other gynecological diseases, polycystic ovary syndrome, the body androgen increase, resulting in sebaceous glands secretion exuberant, which is also more likely to appear acne. In addition, acne on both sides of the cheeks may also be caused by other diseases, it is recommended that patients go to the regular hospital for consultation, a clear diagnosis, and then follow the doctor’s instructions for standardized treatment.