Acne pimples closed mouth is usually considered as acne, removal methods include general treatment, topical medication, oral medication, phototherapy, adjuvant therapy and so on. 1. General treatment: For mild cases, you can usually pay attention to the cleanliness and hygiene of the skin, use some mild cleanser to wash, pay attention to the oil control and moisturizing of the skin, and avoid squeezing and scratching the lesions with your hands. 2. Topical medication: For mild cases, topical retinoids can be used, such as isotretinoin; benzoyl peroxide can also be used to dissolve acne and kill Propionibacterium acnes; topical antibiotics, such as fusidic acid cream, erythromycin, etc., anti-inflammatory and anti-bacterial treatments; and topical azelaic acid can be used to reduce hyperpigmentation. 3. Oral drug treatment: If the effect of simple external drug treatment is not good, oral antibiotic treatment, such as doxycycline, minocycline, etc.; severe acne can be treated with oral isotretinoin, but it has teratogenic side effects and is not suitable for men and women of childbearing age; violaceous acne can be treated with oral glucocorticosteroids, such as prednisone. 4. Phototherapy:Blue light and red light can be used to treat mild to moderate lesions; photodynamic therapy can be used to treat severe acne with topical 5-aminolevulinic acid. 5. Adjuvant therapy: Acne pressurizers can be used to squeeze out the contents of acne. It is recommended that patients use medication in strict compliance with the doctor’s instructions, not blindly self-medication to avoid delay.