Thigh pain needs to be relieved by general treatment, medication, physical therapy and surgery according to the specific cause, with common causes such as trauma or strenuous exercise, osteoarthritic lesions, lumbar spine disease, and so on. 1. Trauma or strenuous exercise: trauma and strenuous exercise may cause thigh pain. If the symptoms are mild, they can be relieved by sufficient rest and local braking. If the pain is significant, ibuprofen and acetaminophen can be taken to help relieve the pain. If the muscle is broken or fractured due to serious trauma, hematoma removal or internal fixation of the fracture should be carried out in a timely manner. 2. Bone and joint lesions: synovitis, degenerative joint disease, etc., due to inflammatory substances, then it will lead to thigh pain. Treatment is mainly based on adequate rest, avoiding weight bearing on joints, ultra-short wave physiotherapy, and at the same time, it can be combined with analgesic drugs and nutritive cartilage drugs, such as ibuprofen and aminoglucose hydrochloride, etc. If conservative treatment is ineffective and the joints are severely damaged, it may lead to thigh pain. If conservatism is ineffective and joint destruction is serious, surgical treatment such as joint replacement can be considered. 3. Lumbar spine disease: lumbar spinal stenosis, lumbar disc herniation can also cause thigh pain, the treatment is mainly based on hot compresses, adequate rest, oral medication, you can choose non-steroidal anti-inflammatory analgesic drugs, such as celecoxib. If the symptoms are more serious, you can choose surgical treatment, such as minimally invasive nucleus pulposus removal surgery. There are many other causes of thigh pain, such as femoral head necrosis, lower limb vascular disease, etc. If rest does not relieve, it is recommended to go to the hospital as soon as possible, complete the relevant examinations, clear the cause of the disease, and then follow the doctor’s instructions to choose the targeted treatment, so as to avoid delays in the condition of the medication need to be applied under the guidance of a doctor.