Many people cannot distinguish between the cheekbones and the maxilla, so first of all, it is clear that the cheekbones are not part of the apple muscle that bulges when a person’s face smiles. The cheekbones are located on both sides of the human head. The bone from the end of the eye to the ear is the cheekbone of the human body, and the part where the apple muscle bulges, that is called the maxilla. If the pain is in the cheekbone, it is most likely caused by a migraine or otitis media, and the inflammation has spread to the cheekbone. If it is a pain in the maxilla, it is most likely caused by rhinitis, or a pain in the maxilla caused by several toothaches in the upper canals.