There are several possible causes of pain in the left cheekbone: 1. Most commonly, a direct violent blow has been suffered, resulting in a blunt contusion. This pain is often accompanied by significant local swelling. 2. Inflammation of the maxilla may be present. For example, a systemic infection in the patient’s body or the use of certain medications may cause necrosis in this area of the maxilla, resulting in pain. 3. It may be caused by prolonged compression. For example, continuous pressure during sleep can lead to constant pain after waking up. 4. It can be caused by chewing hard food. 5. It can be caused by lesions in the adjacent tissues. The most common are sinusitis, mumps, etc. 6. It may be neuropathic pain such as trigeminal neuralgia.