High blood lipids can be caused by poor liver metabolism, poor lifestyle, other diseases, medications and hereditary factors. 1. Poor lifestyle: high intake of food high in cholesterol and saturated fatty acids, lack of exercise, smoking and alcohol abuse. 2. Disease factors: hypothyroidism, Cushing’s syndrome, liver and kidney diseases, systemic lupus erythematosus, myeloma, polycystic ovary syndrome, etc. can affect the synthesis, transportation or metabolism of lipids or lipoproteins, which can lead to secondary elevation of blood lipids. 3. Drug factors: such as thiazide diuretics, β-blockers, glucocorticosteroids, some antitumor drugs and other long-term application can cause secondary elevation of blood lipids and other abnormalities. 4. Genetic factors: part of high blood lipid is due to a single gene or multiple gene mutations, mostly hereditary and aggregation, known as primary hyperlipidemia, such as familial hypercholesterolemia. If you have high blood lipids, you should consult a doctor in time and take treatment under the guidance of a professional physician, and you should not blindly use medication on your own, which may cause adverse consequences.