Although melanoma is a very common malignant tumor nowadays, few people have a clear understanding of this disease. In the clinic, there are many people who do not understand the early symptoms of melanoma, and as a result, they miss the best time for treatment and cause great harm to themselves. 1, skin melanoma has a high degree of harm, rapid growth and mostly poor prognosis, so early diagnosis and timely and correct treatment are very important. The treatment emphasizes early detection and local expansion of excision. However, the clinical manifestations of cutaneous melanoma are complicated and easy to be misdiagnosed, especially the anaplastic melanoma. If early diagnosis is not made, the lesions of melanoma develop aggressively, and lymphatic metastases may occur in early melanoma patients and hematogenous metastases in late stages. If melanoma lesions are located at the extremities, finger (toe) amputation or amputation is often required. Melanoma is the most dangerous type of skin cancer. Melanoma is mostly seen in elderly people, especially in women. Melanoma can be malignant at the beginning, but about 25%-40% of melanoma is caused by malignant transformation of skin pigmentation nevus. Deepening of pigmentation, increase in size, pain, itching, rupture, inflammation, bleeding, and appearance of surrounding are all signs of melanoma malignancy. These are the harmful manifestations of having melanoma. Melanoma is a malignant tumor originating from the neuroectodermal lobe and arising from melanocytes or their mother cells, and its incidence is increasing year by year worldwide. It is worth noting that for chronic skin ulcers that do not heal and superfluous organisms of unknown nature, even if there are no obvious manifestations of melanoma, they still need to be handled with caution, taking into account the possibility of melanoma hazards and timely pathological examination to avoid misdiagnosis and irreversible consequences.