What should I do if my PSA is elevated but my puncture results are negative?

by Specialist

Some patients have an elevated PSA but a negative puncture result.

There are two possibilities for a negative puncture result:

  • One is really negative, which means you don’t have prostate cancer;

  • The other is a “false negative,” which means that no cancerous tumor tissue was punctured and normal prostate tissue was punctured.

How can we tell the difference between these two cases?

This requires the patient to review the PSA every month for 3 to 6 months after a negative puncture and compare it to the PSA before the puncture to dynamically record the changes in PSA.

  • If the PSA is stable at the pre-puncture level or continues to trend downward, prostate cancer is less likely and the PSA only needs to be rechecked regularly in the future.

  • If the PSA is dynamically observed to remain elevated, a repeat prostate puncture biopsy will be needed after 3 months to assist in the diagnosis.