Ischemic changes mean that the brain is in a chronic state of ischemia and hypoxia, leading to neurological problems and possibly coma. Ischemic changes are typically those shown on a brain CT or MRI and are primarily caused by cerebral atherosclerosis. Cerebral atherosclerosis is in turn related to hypertension, hyperlipidemia, diabetes and age, including smoking, drinking and other poor lifestyle, which may lead to atherosclerosis of the blood vessels in the brain. Vasodilators can be applied appropriately, and commonly used drugs include Chuanxiongxiongzine injection and nimodipine tablets. Drugs such as aspirin enteric-coated tablets can also be taken appropriately to inhibit platelet aggregation and prevent thrombosis. Patients should strengthen life management, dietary advice low salt, low fat, drink more water, eat more vegetables, fruits, appropriate exercise. The same disease, the patient’s physical condition is different, different stages of the disease, different treatment methods, should be standardized under the guidance of the doctor.