Recently, a patient consulted online about a skull loss of 7*8 cm due to a fall while riding a bicycle, and he plans to go to Beijing next week to have the skull repaired. In fact, this question is also the voice of most patients, in addition, the safety of surgery is also a topic of concern for patients. Titanium mesh repair still has defects: Now some domestic hospitals are widely carried out is titanium mesh cranial repair, the price is lower, but because the implant material contains metal characteristics, post-operative rejection infection probability, hot and cold reaction sensitive, the imaging medical examination is disturbed. It is also easy to wear the skin material exposed because it takes the covering type repair. Overall, titanium mesh cranioplasty still has various disadvantages and is not the ideal choice for patients with cranial defects. PEEK skull repair and plastic surgery is more effective: peek skull repair and plastic surgery not only effectively improves the disadvantages of titanium mesh skull repair, but also deliberately adds plastic concept for the aesthetic appearance, and makes personalized design for details such as subcutaneous freeing, flap transfer, myofascial flap with tip transfer, and brow arch shaping. After the surgery, the patient’s need for repair is not only met, but also the overall appearance is enhanced. The repair cost of this procedure is mainly related to the area of the defect, the larger the area, the more expensive it may be, and also other examination fees and hospitalization fees. The cranial bone is an important bone to protect and support the brain. After the loss of the cranial bone, from the macroscopic point of view, because the atmospheric pressure acts directly on the brain tissue through the defect area, it will inevitably lead to local brain atrophy and cystic changes over time, which will aggravate the symptoms of brain injury; from the microscopic point of view, for children, the cranial bone defect will become larger with the development of brain tissue, which will affect the normal brain development and low intelligence. For adults, slow reaction, memory loss, epilepsy and even focal neurological signs and symptoms may occur. Therefore, it is important for patients to complete the repair as soon as possible under the arrangement of the doctor after the skull defect.