A cerebral infarct focus refers to an imaging lesion that may be clinically curable with aggressive and correct treatment if the infarct focus is small. If it is a large cerebral infarct, the patient has a large infarct focus and most of them may remain with some stroke capsule after aggressive and correct treatment, and the patient can develop seizures. If the patient is a large cerebral infarction, he or she can also develop impaired consciousness, as well as cerebral edema and increased intracranial pressure, and the patient’s condition is generally severe, and most of them may remain with some sequelae. For patients with large cerebral infarction, thrombolysis should be given as early as possible if it is suitable. If the time window of thrombolytic therapy is exceeded, antiplatelet aggregation, neuroprotection and improvement of blood circulation should be given first. Anti-platelet aggregation is preferred to aspirin, and when aspirin is not tolerated, clopidogrel can also be applied; drugs for neuroprotective treatment, mainly edaravone, cytidine phosphorylcholine and cerebroprotein hydrolysate; drugs for improving blood circulation, clinically applied to sulforaphane, vincristine and trimethoprim. When the patient’s condition is stable, rehabilitation should be given as early as possible to reduce the sequelae and mortality of the patient.