The main adverse reactions of cefixime include gastrointestinal reactions such as diarrhea, shock, rash, blood disorders and renal dysfunction. For its gastrointestinal symptoms such as diarrhea, it can be solved by taking it after meals to reduce the irritation to the gastrointestinal tract. For the allergic symptoms such as shock and rash caused by it, the drug should be stopped immediately and symptomatic treatment should be carried out, and its allergy history should be recorded to avoid using cephalosporins again in the future. For the blood disorders and renal dysfunction caused by it, the drug should be stopped immediately and appropriate disposition measures should be taken. In order to prevent the occurrence of damage, regular checkups should be conducted during the drug administration and the patient’s reaction should be closely observed, and the drug should be discontinued immediately if any abnormality occurs in order to reduce further damage to the organism. In addition, alcohol consumption should also be prohibited during the drug administration to prevent disulfiram-like reactions, and also to avoid aggravating the gastrointestinal adverse reactions of cefixime due to the intake of alcohol.