Side effects of Ezetimibe when taken for a long period of time include abdominal pain and diarrhea, flatulence, and headache, and the medication should be used in accordance with a physician’s instructions. Ezetimibe is mainly used for the treatment of hypercholesterolemia, the drug can produce multi-system side effects with long-term use. The common ones are abdominal pain and diarrhea, gastrointestinal flatulence, fatigue, headache, elevated aminotransferases, myalgia, abdominal pain, malaise, peripheral edema, and elevated aminotransferases, and the less common side effects are cough, dyspepsia, nausea, gastroesophageal reflux, joint pains, dry mouth, and skin rash. The drug is contraindicated in people who are allergic to the components of the drug, patients with active liver disease, pregnant women, as well as lactating women. Treatment of hyperlipidemia should be directed by a physician, and if any adverse reactions occur after the use of the drug, it is necessary to stop the drug and consult a doctor.