There are more reasons for the painful granulation on the inner side of the vulva, which may be caused by condyloma acuminatum, allergy, vulvar cancer and other etiologies. 1. Condyloma acuminatum: Condyloma acuminatum is caused by infection with human papillomavirus and is a sexually transmitted disease. Warts are usually located in the mucous membrane of the vulva and around the anus, and are manifested as skin and mucous membrane organisms of different sizes and shapes, which can be accompanied by pain, itching, and bad odor. 2. Allergy: When women are in the menstrual period, or poor personal hygiene, resulting in allergic reactions to the mucosal tissues around the vulva. Such patients may be accompanied by localized redness, swelling, itching and other symptoms, and in severe cases, granulation may be formed, with obvious pain. In severe cases, granulation may be formed and obvious pain may occur. 3. Vulvar cancer: most patients will have itching and pain of the vulva, granulation lumps or ulcers on the vulva. There are more reasons for granulation pain on the inner side of vulva, so it is recommended to choose suitable treatment plan after relevant examination.