There is no exact time for liver detoxification, it continues 24 hours a day, and the best time is from 11:00 pm to 1:00 pm. During sleep, the brain and extremities use less blood, while the liver has a larger blood supply and a fuller detoxification effect. Chinese medicine believes that after 11:00 p.m., the meridians of qi and blood flow to the bile meridian, and 1:00 p.m. to the liver meridian, and the liver and gallbladder and each other as the table, at this time, the full sleep, can keep the liver and gallbladder detoxification smooth, so the best detoxification period for the liver. If you stay up late, liver fatigue detoxification effect will be affected, may lead to endocrine metabolism is not complete, skin dull, dark circles, fatigue, immunity decline, etc.. If you stay up late for a long time, it will gradually lead to insomnia, forgetfulness, irritability, anxiety and other neurological and mental symptoms. Therefore, it is recommended to go to bed before 10:00 p.m. to facilitate liver detoxification. All patients with liver diseases should avoid staying up late, and they can usually drink more water, do more exercise and develop the habit of going to bed regularly to help detoxify the liver.