Most cases of high-grade cervical lesions can be cured by total hysterectomy, but if the patient still has persistent high-risk HPV infection after surgery, total hysterectomy may also cause vaginal stump lesions. High-grade cervical lesions are precancerous lesions of cervical cancer and can be cured by total hysterectomy in most cases. However, if the patient still has a persistent high-risk HPV infection after surgery, it may cause further high-grade lesions of the vaginal stump, and in severe cases, may even result in cancer of the vaginal stump. High-grade lesions of the cervix, also called severe squamous intraepithelial lesions, belong to the second or third stage of cervical epithelial neoplasia. In most cases, it is caused by infection with human papillomavirus, and can be treated by surgical excision, such as cone excision tumor of the cervix, which can effectively prevent the development to cervical cancer. Patients are advised to go to a regular hospital for examination first, and the doctor will give the most suitable treatment plan according to the examination results.