Whether glomerular microscopic lesions will develop into renal failure is related to the severity of the patient’s condition and whether the patient is actively treated, usually most of the patients will not develop renal failure, but only a few patients may develop renal failure. 1. Minor: A few patients with glomerular microscopic lesions may recover spontaneously within a few months after the onset of the disease. Most of the patients need to receive medication, such as methylprednisolone tablets and glucocorticosteroids, such as prednisone acetate tablets, which usually have a good prognosis and do not cause renal failure. However, if the treatment is not timely, kidney failure may occur. 2. Serious condition: If the patient’s condition is serious, recurrent episodes, or a large amount of urinary protein can not be controlled, and at the same time, the treatment of immune agents is not ideal, it may cause the deterioration of renal disease, a small number of patients may be insensitive to the treatment, resulting in a significant rise in blood creatinine, causing renal insufficiency, and ultimately develop into renal failure. The appearance of glomerular microscopic lesions, it is recommended to timely hospital consultation, under the guidance of physicians and active treatment.