Alcohol skin allergy can appear as patchy edematous erythema on the affected area, on which corn-sized papules, papules, and blisters can be seen, with manifestations of vesicles and oozing, as well as with itchy self-conscious symptoms. In the clinical treatment, it is necessary to order compound glycopyrrolate monoammonium S chloride injection, usually for 7-10 days, together with intramuscular injection of chlorpheniramine maleate, once a day, 1 ml, together with oral administration of olopatadine hydrochloride tablets or fexofenadine hydrochloride tablets. At the same time in the choice of topical medication can be applied to the application of mometasone furoate ointment, applied and then irradiated helium-neon laser, 1 day twice, 1 time 20 minutes, to promote the absorption of drugs as well as play a better anti-inflammatory, promote the effectiveness of microcirculation. It is also important to avoid reapplication of alcohol to the skin, causing aggravation of the irritative reaction.