Low platelets in splenomegaly is considered to be a factor of hematological diseases, such as leukemia, or hypersplenism cannot be ruled out. 1. Leukemia will show symptoms of fever as well as infection in the early stage, and as the disease continues to progress, it will cause anemia as well as lymph node and spleen enlargement. Abnormal levels of low platelets may be seen on routine blood tests. Treatment is usually based on chemotherapy, which can rapidly remove leukemia cells from the body and relieve the condition. Drugs include cytarabine, etc. 2. When hypersplenism occurs, a large number of platelets will be destroyed, resulting in thrombocytopenia and splenomegaly, usually accompanied by a decrease in white blood cells and red blood cells. Primary hypersplenism can be treated with partial embolization, or splenectomy if the effect is not obvious. The causes of splenomegaly and low platelet counts vary from person to person and must be treated under the supervision of a physician.