Gastric poorly differentiated cancer should be actively treated with chemotherapy after metastasis, which has the significance of prolonging life and improving survival rate. According to the degree of cell nuclear differentiation, cancer cells can be divided into highly differentiated, moderately differentiated and lowly differentiated, in which the lower the degree of differentiation, the higher the degree of malignancy of the tumor, the faster the growth rate, and the more prone to metastasis. Therefore, for gastric poorly differentiated cancer, adjuvant chemotherapy should be carried out especially to reduce the probability of recurrence and metastasis of tumor cells. Commonly used chemotherapy drugs include fluorouracil, cisplatin, capecitabine and so on. Once gastric cancer is detected, one should go to regular hospitals in time and choose the most suitable treatment according to the pathological type and cancer stage, so as to improve the quality of life and prolong the survival time.