Hypophosphatemia is a disorder of phosphorus metabolism caused by a lower than normal concentration of phosphate in the circulating blood. 1, clinical manifestations The symptoms of hypophosphatemia are: central nervous system symptoms, such as abnormal sensation, dysarthria, hyperreflexia, tremor, ataxia, coma. Due to decreased erythrocyte 2,3-diphosphoglycerate, the life span of erythrocytes is shortened, which can manifest spherocytosis and hemolysis. Weakness, muscle weakness, muscle pain, and even paralysis. Bone pain (due to osteochondrosis), pseudo-fractures are seen on X-ray films. 2. Diagnosis The most frequent cause of hypophosphatemia is alkalosis (respiratory and metabolic). Usually hypophosphatemia can be identified by the following procedure: after first excluding the cause of alkalosis, urinary phosphate is measured. If urinary phosphate excretion is increased, plasma calcium is measured. If plasma calcium is normal or decreased, consider secondary hyperparathyroidism, rickets or osteomalacia, Fanconi’s syndrome, or hypophosphatemic chondromalacia.