Patients with rigid human syndrome are very rare, when such patients are found, we must have the patience and confidence to help patients do the treatment only, many patients in the early stage, there will be numbness of the limbs, causing great harm to daily life, suffering from rigid human syndrome, what is the method of examination? Examination 1. EMG The resting potential shows a continuous normal action potential, which suddenly increases during the spontaneous spasm period after somatosensory stimulation or passive movement. EMG activity is diminished or absent after sleep or sedation with diazepam, general or cremasteric anesthesia, nulocaine, or argyrotoxic blockade. Chewing eyes are increased due to increased central excitability and enhanced sympathetic activity. 2. Muscle biopsy Usually normal, with mild hyaline degeneration of muscle fibers seen individually. 3. Electroencephalogram Usually normal. 4. Brain crest fluid examination Cell count may be normal, a few have mild elevation of protein or immunoglobulin lgG, lgA, lgM. 5. Blood test: autoimmune antibodies can be detected. 6. Head CT and MRI examination Most of them are not abnormal, and head CT shows small calcified foci. MRI of the head may show transient inflammatory changes or atrophy of the brainstem or high cervical medulla in individual patients. 7. Other There may be increased urinary creatine excretion, but non-specific changes. The patient has a clear grasp of the methods of examination of the stiff person syndrome, the patient must go to the hospital in a timely manner to do the examination and master the treatment, the family should be calm and collected in life, to help the patient together out of the troubles of the stiff person syndrome, in the care of the patient, the family should have patience, try to relieve the pressure in the heart of the patient.