The redness, swelling and itching on the second day after rabies vaccination can be treated by paying attention to diet, anti-allergy drugs, local topical drugs and other methods. 1. Pay attention to diet: the injection site red swelling and itching may be caused by allergy or infection, in the diet to avoid eating spicy and stimulating food to avoid aggravating the condition. 2. Anti-allergic drugs: If the redness, swelling and itching are caused by allergy to rabies vaccine, you can take anti-allergic drugs under the guidance of the doctor, such as loratadine tablets. 3. Local topical drugs: If the injection site is infected with redness, swelling and itching symptoms, you can apply local antibiotic ointment, such as erythromycin ointment, gentamycin ointment and so on. The next day after the rabies vaccination site appears red, swollen and itchy symptoms, can not scratch, pay attention to hygiene, can not touch the water so as not to aggravate the condition. The next day after rabies vaccination, redness, swelling and itching are recommended to go to the hospital in time to avoid delaying the condition.