There are 5 basic points (especially for adults and elderly chronic insomniacs): ① Choose a drug with a short half-life and use the lowest effective dose to reduce the daytime sedative effect. ② Intermittent administration (2 to 4 times per week). ③Short-term administration (no more than 3 to 4 weeks of continuous use). ④ Gradually stop the drug, when suddenly stopping the drug, the drug with a shorter half-life than the drug with a longer half-life withdrawal reaction appears faster and more serious, so stop taking the drug with a short half-life, need to go through a few days of gradual drug reduction process. ⑤ Studies on acute and chronic insomnia have found that the effects of Zolpidem are similar to those of BZ. Since these drugs work by regulating the GABA receptor complex, attention should be paid to drug addiction, and continuous use should not exceed 4 weeks. Alcohol should not be consumed at the same time as the medication, as this increases the risk of drug addiction. Attention should be paid to safety issues before prescribing, such as pregnant women, patients with sleep apnea syndrome, and those with hepatic and renal insufficiency. Because of these problems, the United States has reduced the use of BZ by about 30% in the last 30 years, switching to antidepressants as hypnotics. In particular, SSRIs and other emerging antidepressants (e.g., triazolone, nefazodone) are effective in treating depression-associated sleep disorders with fewer side effects. (6) The most desirable effect of melatonin is the treatment of sleep rhythm disorders, including sleep phase lag, jet lag, sleep disorders caused by shift work, and sleep disorders in blind or brain-injured individuals.