Pancreatic pain is caused by pancreatic enzyme preparations, belladonna tablets, growth inhibitors, prednisone and other drugs. Most pancreatic pain is caused by pancreatic diseases, such as pancreatitis and pancreatic cysts, which not only cause pain, but also damage the function of the pancreas and require timely treatment. Patients with chronic pancreatitis can use pancreatic enzyme preparations for replacement therapy to promote the normalization of the total amount of pancreatic enzymes in the duodenum. For patients with severe pain, they can take oral belladonna tablets, which can not only inhibit the release of acetylcholine, but also release smooth muscle spasm, thus relieving pain. During an acute attack of pancreatitis due to excessive secretion of pancreatic fluid, thus leading to self-digestion of the organ, growth inhibitors can be used for relief. Growth inhibitors can inhibit the secretion of insulin pancreatic fluid and alleviate the patient’s symptoms. Some patients with pancreatic pain are caused by autoimmune pancreatitis disease and should be treated with medication in combination with prednisone drugs for immunotherapy.