Xiaoqiong is 6 years old, in kindergarten class, and is 115 cm tall, which is obviously short. When her mother heard that she could get a shot that could make people grow taller, she rushed to the hospital and asked the doctor to dispense such a shot, but the doctor did not dispense it to her, saying that some short children are suitable for such a shot while others are not and need to undergo relevant tests. The production and adequate supply of genetically engineered recombinant human growth hormone (hereafter referred to as growth hormone hGH) has facilitated clinical research on the treatment of various diseases of short stature with growth hormone. So far, it has been confirmed that treatment with growth hormone is effective for dwarfism caused by the following diseases: (1) Growth hormone deficiency
According to the current summary of clinical efficacy in large numbers and over a relatively long period of time, it has been shown that if treatment is started at an early age and the dosage of growth hormone is adequate, treatment continues until puberty when there is no more growth. In growth hormone deficiency, it is possible to achieve the height of an adult. (2) Congenital Ovarian Hypoplasia Syndrome Patients are short in stature and have an average adult height of about 140 cm if left untreated. If treated properly with growth hormone, the height can be increased by 10~16 cm. (3) Children born at less than gestational age with persistent short stature The cause of short stature is intrauterine growth retardation, and the weight at full term is less than 2.5 kg (or less than the 10th percentile of the weight of children of the same gestational age).
About 15% of these children continue to be short after birth. Recent research has demonstrated that growth hormone can promote growth in these children with short stature. The growth rate increased 1-fold after 2 years of treatment. (4) Chronic renal insufficiency-induced dwarfism Some studies have reported that children with growth retardation due to this condition treated with growth hormone have accelerated their height growth by 3-6 cm per year compared to those who have not been treated with growth hormone. (5) Idiopathic dwarfism
Children with idiopathic dwarfism are those for whom no cause of dwarfism can be found at the current level of diagnosis, and the results of treatment are inconsistent among reports. Some report that it is effective with relatively high doses, with accelerated growth rate and lifelong height increase of 5~7cm; some report that with normal treatment amount, there is no significant increase in final height in adulthood. However, growth hormone is not used to improve height in children with normal short stature.