SLE is a systemic autoimmune disease that affects multiple systems and organs of the body and therefore has a complex and varied clinical presentation. Most patients with SLE have varying degrees of skin lesions that manifest as various types of rashes, which are generally not itchy. The pathogenesis of SLE is currently thought to be related to genetic, estrogenic, infectious, ultraviolet, and pharmacologic factors, with abnormal immune inflammation as its causative feature. In terms of pathogenesis and pathological features, SLE can cause fever, fatigue, joint pain, loss of appetite, and mouth ulcers, but does not usually cause itching. Even if the skin lesions are prominent, such as pteroid erythema, discoid erythema, reticulocytosis, Raynaud’s phenomenon, etc., they are mostly not pruritic. However, due to the complexity of SLE and the variety of clinical manifestations, it is very easy to combine a variety of other diseases, such as allergies, infections, or pruritic diseases, which can also cause pruritus. In addition, patients with SLE need to use glucocorticoids, immunosuppressants and other drugs for a long time, which will have certain effects on the normal resistance of the body, and some of these drugs will cause itching and other adverse reactions. Therefore, SLE is not a pruritic disease. If itching sensation occurs, you should immediately consult a doctor to find the cause and provide targeted treatment.