There are three ways to deal with multiple nodules found on breast examination: First, for women over 35 years of age, it is recommended to increase the number of mammograms to detect suspected malignant lesions. Secondly, it is recommended to increase the number of breast MRIs in order to interpret suspected malignant lesions detected by ultrasound or molybdenum films. Thirdly, it is also the most common and practical, that is, the doctor adopts ultrasonography to analyze and evaluate the multiple nodules one by one, whether the boundary of the nodule is intact, whether there is any peritoneum, whether it is hypoechoic, anechoic, or mixed echogenicity, whether the echoes at the back of the nodule are strengthened or weakened, and whether there is any suspected calcified foci accompanied with the size of longitudinal and transversal bases and so on. The patient’s diagnosis was made on a case-by-case basis. These multiple nodules are categorized by careful evaluation of the nodules one by one. For nodules below category III, the likelihood of malignancy is about 2%, and the likelihood of benignity is more than 98%. Follow-up observation is recommended for such nodules, and for nodules in category 4 or higher, 4A, 4B, etc. and so on, minimally invasive pathology is recommended if necessary.