Treatment is usually not needed if the hepatitis B 4.5 is positive alone, but treatment is needed if liver function is impaired. Hepatitis B 4.5 is positive for e-antibody, which means that the replication of the virus is weakened, and 5 is positive for core antibody, which means that you have had or have hepatitis B. If the surface antigen is negative at this time, it means that you have had hepatitis B and do not need to be treated. If the surface antigen of hepatitis B is negative, it means that you have had hepatitis B and do not need treatment. If the surface antigen is positive, you need antiviral treatment, and you should take interferon or nucleoside drugs under the instruction of your doctor. If the surface antigen is negative, it should also be noted that it may be occult hepatitis B. It can be detected by liver puncture, and if it is diagnosed as occult hepatitis B, antiviral treatment is also needed.