The palm of the hand is very red and itchy, may be contact dermatitis, frostbite, angioneurotic edema and other diseases caused by the patient should consult a doctor in a timely manner to clarify the cause of the disease for appropriate treatment. 1. Contact dermatitis: the palms of the hands due to contact with certain sensitizing or irritating substances after the occurrence of allergic or irritating reactions, which can be manifested as red palms, itching. 2. Frostbite: red and itchy palms may also be caused by frostbite, mostly occurring in the colder seasons, there will be localized erythema, blisters, itching and pain will be aggravated by heat. 3. Angioneurotic edema: the etiology is unknown, mostly related to heredity, may lead to edematous erythema in the palm of the patient, accompanied by pain, itching, burning sensation. Palm is very red and itchy, there may be other causes, need to actively seek medical attention, clear cause for targeted treatment.