Coffee is not recommended for taking amoxicillin. Amoxicillin is hydroxybenzylpenicillin, which belongs to a class of antibiotics commonly used in clinical practice. It can mainly be applied to infections such as Streptococcus haemolyticus, Escherichia coli and Helicobacter pylori. Coffee contains a large amount of caffeine content, taking antibiotic drugs and then drinking coffee, easy to affect the efficacy of the drug. In addition, amoxicillin will produce a certain stimulation of the patient’s gastrointestinal tract, caffeine content will also be, the two together with the patient’s gastrointestinal burden and mucosal stimulation. Amoxicillin has nausea, vomiting, pseudomembranous enteritis, causing anemia and other adverse reactions, it is recommended to use the drug under the guidance of a doctor, not blindly self-medication to avoid adverse effects.