It is common to see oral herpes in small children in pediatric clinics. Parents of children will say that their children do not eat food and saliva, older children will say that their mouth or oral cavity is sore, and some have low or even high fever. The most disturbing thing is the lack of milk and food and crying. Oral herpes or mouth ulcers are relatively common and the pathogens are mostly viruses! Very occasionally it is bacteria. On physical examination, you will find that the child is uncooperative on physical examination, and on serious examination you will find one or several blisters on the lips, tongue or tongue surface, or oral mucosa like a volcanic crater, red next to it, with clear blister-like material in the middle, and very few children will bleed locally! It is important to look for blisters on the palms of the hands and soles of the feet, and one must be alert for hand, foot and mouth disease. The doctor’s examination also includes the heart, lungs and nervous system. The diagnosis is clear. Treatment principles include three aspects: first, local treatment, second, systemic medication, and third, to improve resistance. The simplest local treatment is to rinse with slightly concentrated saline three to four times a day, and older children can rinse with light saline three times a day. The second method is to apply topical iodine glycerin to the blisters of the mouth twice a day. Systemic medication: You can choose western medicine, such as ribavirin granules, valacyclovir tablets or ganciclovir tablets, for a course of five to seven days. Chinese herbal medicine can be used, such as Jin Lian Qing Fever Infusion Tablets, Pudilan Anti-inflammatory Oral Liquid, Kou Yan Qing Granules or Chai Yin Oral Liquid, etc. Choose one of them. Regarding the improvement of resistance: you can take pidomod oral solution and spleen amino peptide dry powder orally for fifteen days. If oral herpes keeps recurring, pay attention to any abnormalities in the immune system.