If you have high fever after taking DPT vaccine, you can use physical cooling and medication to reduce the fever, and you should go to the hospital as soon as possible if the condition is serious. 1. Physical hypothermia: high fever after taking DPT vaccine, many of them are adverse reaction of vaccine, you should pay attention to drink more water, and use antipyretic paste, warm water bath, ice bag to reduce temperature. 2. Drugs to reduce fever: high fever will cause discomfort, but also cause water and electrolyte disorders, you can appropriate drugs to reduce fever, such as ibuprofen, Xiao Chaihu granules, compound aminobarbital, acetaminophen and other antipyretic treatment. If the fever does not go down, it is recommended to go to the fever clinic of the hospital to improve the inflammation index and evaluate whether it is combined with other infectious diseases before appropriate treatment.