The difference between intestinal tuberculosis and Crohn’s is that the causes are different, the symptoms are different, the prognosis is different, and the treatment is different. 1. Different etiology: intestinal tuberculosis is mainly caused by human mycobacterium tuberculosis, and it may also be caused by the primary lesion through hematogenous dissemination and direct spread. Crohn’s disease may be related to immune factors, infectious factors, genetic factors, etc. It is mostly found in the terminal ileum and adjacent colon. 2. Symptoms are different: intestinal tuberculosis is mainly located in the ileocecal region, but also involves the colorectum, often accompanied by tuberculosis, mainly manifested as abdominal pain, change in bowel habits, abdominal mass, low fever, fatigue and other symptoms. Crohn’s disease is chronic, the length of the active period and remission alternating, a few acute onset, will be manifested as acute abdomen, abdominal pain, diarrhea, weight loss is the main manifestation of the disease. 3. Different prognosis: when intestinal tuberculosis is serious, the pain is obvious, without active treatment, some patients will have intestinal obstruction, tuberculous peritonitis, etc., usually can’t be self-healing. If Crohn’s disease is not treated in time, it will cause intestinal obstruction, and some patients can relieve themselves. 4. Treatment is different: patients with intestinal tuberculosis, need to pay attention to supplemental nutrients, eat more easily digestible, non-irritating food, but also through drugs, such as isoniazid, rifampicin and so on. Crohn’s disease can be under the guidance of a doctor, through the use of drugs for treatment, such as azathioprine, infliximab and so on. Patients who are not feeling well need to go to the regular hospital in time, under the diagnosis of the doctor, according to the patient’s condition, to take targeted treatment.