Atrial septal defect is a form of congenital heart disease and must be diagnosed by cardiac ultrasound to give a treatment plan. If the site and type of defect can be suitable for interventional septal defect blocking treatment, this minimally invasive treatment is needed to restore the patient’s health. The size of the atrial septal defect and the size of the blocker is 3.5 cm at the largest and 3-5 mm at the smallest are indications for the blocker, which can be self-controlled according to size and shape to cure the atrial septal defect. After the surgery, it is necessary to take long-term cardiotonic, diuretic, and myocardial nutrients such as digoxin and spironolactone, and to review the dosage of the drugs regularly according to the results of the review.