Enlargement of one side of the bladder may be caused by cystitis, bladder tuberculosis, bladder tumor, according to the cause of drug treatment, surgical treatment. 1. Acute cystitis caused by bacterial infection, there will be frequent urination, urinary urgency, urinary pain and one side of the bladder is enlarged, usually take levofloxacin tablets, amoxicillin clavulanate potassium tablets treatment. 2. Bladder tuberculosis caused by Mycobacterium tuberculosis can also lead to enlargement of one side of the bladder, after the bacterial culture to confirm the diagnosis, to anti-tuberculosis drug treatment, such as isoniazid, rifampicin, etc., pay attention to the early, combined, appropriate amount, regular, the principle of the whole drug. 3. If the enlargement of one side of the bladder is caused by bladder tumor, surgical treatment should be the main treatment and supplemented by radiotherapy. It should be noted that when the condition is not relieved or the symptoms progressively aggravate, the patient should go to the hospital in time for examination and treatment under the doctor’s guidance.