The so-called multidrug resistance is a kind of bacterial resistance, and bacteria develop resistance mainly because they are more resistant to various antibiotics, including the original antibiotics that can kill bacteria and currently become resistant. Bacterial resistance includes both naturally acquired and acquired, i.e. selective pressure or overuse of antibiotics causing increased bacterial resistance. Some resistance arises with antibiotic use, bacteria produce changes in membrane structure, changes in cell membrane permeability, resulting in resistance to antibiotics, and multidrug resistance to some extent indicates that bacteria are resistant to multiple antibiotics. A specific clinical category of bacteria, such as non-fermentative bacteria, is often described by MDR as bacterial multi-drug resistance, which refers to resistance to all three or two or more antibiotics commonly used in clinical practice.