Kidney disease with less nocturia may be improved or the disease may be aggravated. Kidney disease is caused by various reasons of the patient’s kidney structure as well as its function has changed, in the urine of the clinical manifestations are mainly increased or decreased urine, yellowish urine, hematuria, proteinuria, as well as urinary frequency, urinary urgency and other urinary abnormalities. If the patient after the occurrence of kidney disease positive, standardized treatment, the night urine is less likely to be damaged cells of the renal tubules to be restored, caused by the improvement of the disease. However, if the patient is not treated in time after the occurrence of the disease, the decrease in nocturia may also be caused by the deterioration of the disease, resulting in a further decrease in glomerular filtration rate. Therefore, when abnormal urine output occurs in patients with kidney disease, it is recommended to go to the hospital for timely examination and active treatment.