Differential blood pressure is the pulse pressure difference, reaching 80mmHg suggests that the pulse pressure difference is increasing, the corresponding condition and the specific cardiovascular function are closely related, the most common causes include aortic valve closure insufficiency, atherosclerosis, hyperthyroidism, etc., which need to be combined with the clinical symptoms and examination to determine the comprehensive. 1. Aortic valve insufficiency: the corresponding lesion mainly leads to systolic blood partially returning to the heart, resulting in a decrease in systolic blood pressure, and an increase in blood volume in the heart, leading to a rise in systolic blood pressure, which leads to an increase in the difference in pulse pressure. 2. Arteriosclerosis: Arteriosclerosis is mainly caused by a decrease in the compliance of the blood vessel wall, which leads to a rise in systolic blood pressure and a decrease in diastolic blood pressure, resulting in an increase in the pulse pressure difference. 3. Hyperthyroidism: Hyperthyroidism leads to strong contraction of the heart muscle, causing systolic blood pressure to rise, and because the thyroid hormone itself will lead to vasodilatation, resulting in a decrease in diastolic blood pressure, which leads to an increase in the pulse pressure difference. Other causes such as congenital heart disease, rheumatic heart disease, anemia, etc. can also lead to increased pulse pressure difference. Pulse pressure difference of 80mmHg, further investigation needs to be combined with ultrasonography and clinical examination to make a comprehensive judgment, the emergence of obvious symptoms of dizziness and discomfort, the need to consult a doctor in a timely manner, under the guidance of the clinician for standardized treatment.