Under normal circumstances, 2 hours postprandial blood glucose should be lower than 1 hour postprandial blood glucose, if 2 hours postprandial blood glucose is higher than 1 hour postprandial blood glucose, there may be insulin resistance and abnormal insulin secretion in the body. 1. Insulin resistance: when there is insulin resistance, pancreatic β-cells still secrete insulin normally after eating, but due to genetic, obesity, disease and other factors, insulin cannot promote the absorption of glucose in the blood by the liver cells, fat cells, muscle tissues, etc., which will lead to abnormal glucose metabolism, and the blood sugar in 2 hours after meal will be higher than that in 1 hour after meal. 2. Abnormal insulin secretion: As the insulin secreted by pancreatic β-cells decreases or fails to be secreted, the glucose in the blood after eating cannot be effectively utilized, and the 2-hour postprandial blood glucose is higher than the 1-hour postprandial blood glucose may also occur. 3. Coexistence of insulin resistance and abnormal secretion: If both conditions exist at the same time, the glucose in the blood cannot be broken down and metabolized after eating, and in this case, the blood glucose at 2 hours after meal may be higher than that at 1 hour after meal. When the blood glucose of 2 hours after meal is higher than that of 1 hour after meal, you should consult the doctor in time, clarify the cause of the disease and standardize the treatment under the doctor’s guidance.