Penicillin is best dispensed in a 0.9% sodium chloride solution. Penicillin is a beta-lactam antibiotic with bactericidal properties and is a broad-spectrum antibiotic with good antimicrobial activity against gram-positive gram-negative bacteria as well as anaerobes. Penicillin needs to be dissolved and administered intravenously. It is usually administered in 0.9% sodium chloride solution. Because beta-lactams are time-dependent antibiotics, they are generally used twice a day or 6 hours, 8 hours or 12 hours frequently. Penicillin is easily broken down and unstable in glucose solution, and its metabolites may cause allergic reactions. The use of antibiotics should be under the guidance of the doctor for the condition and the correct use of drugs, avoid self-medication. Otherwise, it may not only not be able to play a role in the treatment of the disease, but also may lead to bacterial drug resistance.