Genital herpes is a viral disease, and patients should not be vaccinated temporarily during the acute onset of the disease, or there is some possibility of exacerbation of the disease, or even more serious vaccine reactions. During certain acute illnesses, or during the acute onset of certain chronic diseases, most vaccines should not be vaccinated, and genital herpes can present acute symptoms, or recurrent symptoms after clinical cure, during the onset of the disease, it will lead to blisters, vesicles, or superficial ulcers on the patient’s external genitalia and other parts of the body, accompanied by itching, tingling and other symptoms. Vaccination during this period may exacerbate the development of the disease and is not conducive to recovery. In addition, during the period of illness, the body’s resistance is poorer, and after vaccination, patients may experience some serious vaccine reactions, such as fever, rash, or even anaphylactic shock. Different vaccines have different contraindications and it is recommended to follow the doctor’s arrangement as to whether they can be vaccinated or not. Serious vaccine reactions after vaccination should also be handled by a doctor in a timely manner.