Gastrointestinal mesenchymal tumors are common mesenchymal-derived tumors of the GI tract and account for the majority of GI mesenchymal tumors. In general, there is no specific time for high-risk recurrence of gastrointestinal mesenchymal tumors; they may remain unremitting, or they may recur within two years. When gastrointestinal mesenchymal tumor first occurs, it will generally be benign tumor, if the patient finds out and consults the doctor in time, after the tumor is removed through surgical treatment or targeted therapy in regular hospitals or the corresponding therapeutic drugs for the cancer-causing parts that have been clearly identified, then the tumor will be under control, and there is a possibility that it may not recur all the time. However, if the patient suffers from high-risk gastrointestinal mesenchymal stromal tumor and it is not detected in time, even after surgical resection or targeted therapy, the tumor may recur or the cancer cells may metastasize within two years with the spread of the cancer cells and the mutation of the genes. If a patient suffers from high-risk gastrointestinal mesenchymal tumor, he or she should pay attention to regular review to observe the changes in the patient’s body.