Creatinine 133μmol / L can be maintained for a few years, first need to clarify the cause of the disease, physiological factors elevated, remove the triggers can be restored to a healthy level; pathologic factors elevated prognosis of individual differences, can not be generalized. 1. Physiological factors: If the creatinine is elevated by recent high protein diet, eating a lot of lean meat, strenuous activities, etc., the creatinine can be restored to a healthy level after a vegetarian diet and rest. 2. Pathological factors: If it is acute renal failure, follow the doctor’s advice to clarify the acute factors, such as stone obstruction, drugs, etc., most of them can be fully recovered after removing the causes. Such as chronic glomerulonephritis, diabetic nephropathy, lupus nephritis and other causes of renal failure, the patient is older, poor health, treatment is not timely, may be 5 years to progress to uremia; by polycystic kidney, chronic interstitial nephritis and other causes of renal failure, the age of the younger, better health, treatment is more timely, may be 10 years will not progress to uremia, so do not make generalizations. When you find creatinine 133μmol/L, you should go to the hospital in time, improve the relevant examination under the guidance of the doctor, clarify the cause of the disease, and follow the doctor’s instructions for symptomatic treatment to slow down the progress of the disease.