As an important part of the human body, the brain has an important role in driving people’s moods, making decisions and taking actions in daily life. While people cannot help but praise its powerful functions, they are not aware that there is a natural helmet on the surface of the brain that is always protecting our brain from external damage, and this helmet is our skull. In spite of all the preventions, we still can’t avoid some accidents, such as car accidents, collisions, falls, etc., which can cause brain damage, and many patients need to be treated by debridement and decompression, leaving skull defects and serious head collapse. Without the protection of the skull, it is not only easy to cause instability of intracranial pressure or intracranial abnormalities and other conditions, but also easy for patients to develop psychological disorders, low self-esteem, depression, irritability, etc. Therefore, cranial repair is needed in a timely manner. Although titanium mesh cranial repair is widely used in some domestic hospitals in neurosurgery to perform cranial repair for patients, the postoperative feedback is poor. So, what are the contraindications after titanium mesh skull repair? It is found that titanium mesh is essentially a metal property, taking the overlay repair method, and the material performance is not good, the tissue compatibility is not ideal, the heat insulation is not good, the hardness is not high, the shaping effect is not good, and there may be many complications after the operation, the common ones are rejection infection, titanium mesh exposure, CT MRI is affected, etc. Therefore, patients should further seek more advanced and mature technology when preparing for skull repair. Currently, polyetheretherketone peek cranioplasty is carried out to achieve four technical innovations based on the summary of hundreds of cases with the advanced concept of precise repair + cosmetic plastic surgery. This technology, with peek as the implant material, can effectively avoid the many shortcomings of titanium mesh cranioplasty. In addition this technology develops individualized repair and plastic plan for each patient with skull defect, ensuring both sides contralateral after surgery and high aesthetic appearance. There are also unique material edge, thickness, mesh aperture design, unique tissue separation and repositioning technology, and cosmetic plastic surgery technology to finally achieve the unity of anatomical integrity, functional perfection, and aesthetic appearance.