A high anti-Dsg1 antibody result may indicate the presence of pemphigus. Pemphigus is an autoimmune skin disease that usually occurs in middle-aged and elderly people aged 50 to 60 years old and manifests itself in the form of blisters that can easily rupture on the skin, which secrete watery fluid after bursting, accompanied by itching or pain, and the blisters are usually found on the chest and head. Clinical diagnosis of pemphigus is mainly based on the patient’s clinical symptoms and laboratory tests to determine, serological examination can see anti-Dsg1 antibody positive, smear can see pemphigus cells is the main basis for confirmation of the diagnosis. If the level of anti-Dsg1 antibody is found to be too high, it is recommended to consult the dermatology department of regular hospitals to determine the severity of the disease according to the skin damage.